Chronic Fatigue Syndrome was first dubbed the Yuppie flu in the 1980's, because it seemed to be concentrated in young, affluent white professionals and the subjective nature of the symptoms. Now chronic fatigue and immune dysfunction syndrome, afflicts an estimated three to four million people in North America alone. Can I just observe that this is the starting time of the age of the computer. Chronic Fatigue syndrome and Fibromyalgia both occur with a cluster of symptoms that include deep fatigue unrelieved by sleep, muscle and joint pain or weakness, headache, memory loss, mental confusion and poor concentration, digestive problems, recurring infections, low grade fever, often in the afternoon, swollen lymph glands, food and environmental allergies and sensitivities, severe exhaustion from minor activity and - depression. - ( I wonder why ) I wrote sarcastically. How could you not be depressed with all that going on. Also other symptoms include dizziness, anxiety attacks, night sweats, rashes, breathing irregularities, irregular heartbeat, and hypersensitivity to heat and cold and to light and sound.
There is no single cause of chronic fatigue syndrome or Fibromyalgia. Multiple factors combine to overwhelm the immune system. They may be virus and low grade infections, candidiasis, underactive thyroid gland, stress and adrenal exhaustion, toxic overload, nutritional deficiencies, allergies and the extensive use of antibiotics, hydrocortisone and / or vaccinations. Also chronic exposure to environmental pollutants and food allergies..
PESTICIDE EXPOSURE
According to the cdc the symptoms of pesticide exposure look very much like the symptoms of Chronic Fatigue and even more so, Fibromyalgia. Clinical signs and symptoms of malathion intoxication are typical of organophosphate poisoning. Malathion and its metabolite, malaoxon, inhibit the enzyme acetylcholinesterase and thus, prevent the hydrolysis of the neurotransmitter acetylcholine in the central and peripheral nervous systems. Continuous presence of acetylcholine at parasympathetic autonomic muscarinic receptors results in ocular effects (miosis, blurred vision), gastrointestinal effects (nausea, vomiting, abdominal cramps, diarrhea), respiratory effects (excessive bronchial secretions, chest tightness, bronchoconstriction), cardiovascular effects (bradycardia, decreased blood pressure), effects on exocrine glands (increased salivation, lacrimation), and effects on the bladder (incontinence). At the level of parasympathetic and sympathetic autonomic nicotinic receptors, acetylcholine will induce tachycardia and increase blood pressure. At the neuromuscular junction, excess acetylcholine will induce muscle fasciculations, cramps, diminished tendon reflexes, muscle weakness in peripheral and respiratory muscles, ataxia, and paralysis. Finally, overstimulation of brain cholinergic receptors will lead to drowsiness, lethargy, fatigue, headache, generalized weakness, dyspnea, convulsions, and cyanosis. The signs and symptoms described above have been documented in almost all of the cases of accidental or intentional ingestion of high amounts of malathion and in cases of dermal intoxication. Lethal doses can be estimated from case reports to have been between 350 and 2,000 mg/kg. These dose levels usually inhibited plasma and RBC cholinesterase activities to levels ranging from undetectable to 10–30% of normal. Studies of workers exposed to a combination of pesticides, including malathion, have shown decreases between 10 and 50% in both plasma and RBC cholinesterase activities. In general, plasma cholinesterase activity can be inhibited by 20–25% without significant physiological consequences. Studies also have shown that the rate of decrease of RBC cholinesterase correlates better with appearance of symptoms than the absolute value reached after exposure. It was found that plasma cholinesterase activity in workers who exhibited cholinergic symptoms and signs was 17% lower than in workers without symptoms and signs. Similar findings were reported in another study (Ernest et al. 1995). No cholinergic signs were seen in a study in which the activities of RBC and plasma cholinesterase varied less than 10% between pre- and postexposure. A study in volunteers exposed to 85 mg/m3 of a malathion aerosol for 2 hours/day over a 42-day period observed no clinical signs and no significant inhibition of plasma or RBC cholinesterase activity over the study period. In an additional study of volunteers orally administered 0.34 mg malathion/kg/day for 56 days, there was a maximum depression of 25% in plasma cholinesterase approximately 3 weeks after cessation of treatment. A similar depression in RBC cholinesterase was observed, but occurred later. Administration of 0.11 mg malathion/kg/day for 32 days or 0.23 mg/kg/day for 47 days did not produce any significant depression of plasma or RBC cholinesterase activity. No clinical signs were seen in the volunteers. As detailed in Section 3.2, numerous studies in animals exposed to malathion by any route have shown inhibition of plasma, RBC, and brain cholinesterase activities.
Here at Sunnyslope Healing Arts we have seen substantial improvement in all the symptoms of Fibromyalgia and Chronic Fatigue syndrome in our patients who have had treatments to clear pesticides from their bodies, sometimes just as stunning as the results for our patients with Endometriosis. If you have Fibromyalia or Chronic Fatiue syndrome it is highly recommended that you get checked for pesticides to see if they are a mitigating factor in your illness.